diff --git a/RELEASE_NOTES.md b/RELEASE_NOTES.md
index 0b61ac9f5..b42a861e1 100644
--- a/RELEASE_NOTES.md
+++ b/RELEASE_NOTES.md
@@ -20,6 +20,9 @@ In this release, we have introduced pedantic warnings to enhance C++ standard co
 
 ### Supported platforms
 
+Python API requires [Cppyy](https://cppyy.readthedocs.io/en/latest/installation.html) and has only
+been tested on Linux. The latest known version to work with ns-3 is cppyy==3.1.2.
+
 ### New user-visible features
 
 - (network) !1828 - Added a common helper to create and install applications
diff --git a/doc/installation/source/linux.rst b/doc/installation/source/linux.rst
index 663eb66b8..3d728101f 100644
--- a/doc/installation/source/linux.rst
+++ b/doc/installation/source/linux.rst
@@ -103,9 +103,14 @@ Please see below subsections for Python-related package requirements.
 Python bindings
 ===============
 
-Python requires `Cppyy, <https://cppyy.readthedocs.io/en/latest/installation.html>` and specifically, version 2.4.2 is the latest version known to work with ns-3 at this time.
+Python requires `Cppyy, <https://cppyy.readthedocs.io/en/latest/installation.html>` and specifically,
+version 3.1.2 is the latest version known to work with ns-3 at this time.
 
-ns-3.37 and newer::
+ns-3.42 and newer::
+
+  python3 -m pip install --user cppyy==3.1.2
+
+ns-3.37-3.41::
 
   python3 -m pip install --user cppyy==2.4.2
 
diff --git a/doc/installation/source/system.rst b/doc/installation/source/system.rst
index 1641022ac..eac22f778 100644
--- a/doc/installation/source/system.rst
+++ b/doc/installation/source/system.rst
@@ -140,8 +140,10 @@ if you are running LTE or NR simulations (which make use of SQLite databases):
 Python bindings (ns-3.37 and newer)
 ===================================
 
-|ns3| Python support now uses `cppyy <https://cppyy.readthedocs.io/en/latest/>`_.  Version 2.4.2
-is the most recent supported cppyy release; version 3.0.0 is not currently supported.
+|ns3| Python support now uses `cppyy <https://cppyy.readthedocs.io/en/latest/>`_.  Version 3.1.2
+is the most recent supported cppyy release since ns-3.42.
+
+Cppyy version 2.4.2 should be used from ns-3.37 up to 3.41.
 
 Due to an `upstream limitation with cppyy <https://github.com/wlav/cppyy/issues/150>`_, Python bindings do not work on macOS machines with Apple silicon (M1 and M2 processors).
 
diff --git a/doc/manual/source/python.rst b/doc/manual/source/python.rst
index 5b1a13173..27b7b7fb6 100644
--- a/doc/manual/source/python.rst
+++ b/doc/manual/source/python.rst
@@ -111,11 +111,11 @@ simple modules in python, jump to the `Using the pip wheel`_ section.
 Using the bindings from the ns-3 source
 =======================================
 
-The main prerequisite is to install `cppyy`, with version no later than 2.4.2.
+The main prerequisite is to install `cppyy`, with version 3.1.2.
 Depending on how you may manage
 Python extensions, the installation instructions may vary, but you can first
 check if it installed by seeing if the `cppyy` module can be
-successfully imported and the version is no later than 2.4.2:
+successfully imported and the version 3.1.2:
 
 .. sourcecode:: bash
 
@@ -125,7 +125,7 @@ successfully imported and the version is no later than 2.4.2:
   Type "help", "copyright", "credits" or "license" for more information.
   >>> import cppyy
   >>> print("%s" % cppyy.__version)
-  2.4.2
+  3.1.2
   >>>
 
 If not, you may try to install via `pip` or whatever other manager you are
@@ -133,7 +133,7 @@ using; e.g.:
 
 .. sourcecode:: bash
 
-  $ python3 -m pip install --user cppyy==2.4.2
+  $ python3 -m pip install --user cppyy==3.1.2
 
 First, we need to enable the build of Python bindings:
 
diff --git a/pyproject.toml b/pyproject.toml
index 18b1293c1..754779410 100644
--- a/pyproject.toml
+++ b/pyproject.toml
@@ -5,7 +5,7 @@ requires = [
     "setuptools>=45",
     "setuptools_scm[toml]>=6.0",
     "cmake-build-extension>=0.4",
-    "cppyy==2.4.2",
+    "cppyy==3.1.2",
 ]
 
 [tool.setuptools_scm]
diff --git a/setup.cfg b/setup.cfg
index 679a7d3d9..342e29711 100644
--- a/setup.cfg
+++ b/setup.cfg
@@ -40,5 +40,5 @@ classifiers =
 zip_safe = False
 python_requires = >=3.6
 install_requires =
-    cppyy==2.4.2
+    cppyy==3.1.2
 
diff --git a/utils/tests/gitlab-ci-cppyy.yml b/utils/tests/gitlab-ci-cppyy.yml
index 930196053..bfdab3500 100644
--- a/utils/tests/gitlab-ci-cppyy.yml
+++ b/utils/tests/gitlab-ci-cppyy.yml
@@ -11,7 +11,7 @@ cppyy-22.04:
       python3 python3-pip
       libboost-dev libgsl-dev libgtk-3-dev
       git wget
-    - pip install cppyy==2.4.2 matplotlib numpy
+    - pip install cppyy==3.1.2 matplotlib numpy
   script:
     - ./ns3 configure -G Ninja --enable-python-bindings
     - ./ns3 build
@@ -42,7 +42,7 @@ cppyy-20.04:
       python3 python3-pip
       libboost-dev libgsl-dev libgtk-3-dev
       git wget
-    - pip install cppyy==2.4.2
+    - pip install cppyy==3.1.2
   script:
     - ./ns3 configure -G Ninja --enable-python-bindings
     - ./ns3 build
@@ -69,7 +69,7 @@ cppyy-20.04:
     # Upgrade the pip version to reuse the pre-build cppyy
     - python -m pip install pip --upgrade
     - python -m pip install setuptools setuptools_scm wheel --upgrade
-    - python -m pip install auditwheel cmake-build-extension cppyy==2.4.2
+    - python -m pip install auditwheel cmake-build-extension cppyy==3.1.2
     # Configure and build wheel
     - python setup.py bdist_wheel build_ext
     - export EXCLUDE_INTERNAL_LIBRARIES=`python ./build-support/pip-wheel/auditwheel-exclude-list.py`